Hi Abe, do you mean the axle is falling out of the dropouts?
If the axle is fitting into the dropouts correctly and the nuts are properly tightened it should not fall out.
If the dropouts are worn and the axle is a loose fit in the dropout it can sometimes work loose with constant acceleration and regen braking trying to twist the axle in different directions.
A torque arm can be used to prevent the twisting forces from turning the axle but if the axle is tightened correctly, it should not twist in the first place.
Sometimes it is necessary to file the slot deeper into the frame to allow the axle to fit in more, but you need to be careful that you don't file away too much metal and weaken the dropouts too much in the process.
Can you post a picture showing a close up of the axle in the dropouts so we can see if there is an obvious problem?
Alan